TABLE 7.
In vitro activity of meropenem and cefepime combined with xeruborbactam or taniborbactam against carbapenem-resistant strains of Enterobacterales with a functional or defective OmpK36 according to carbapenemase production a
| MEM + XER (4) | MEM + XER (8) | MEM + TAN (4) | FEP + XER (4) | FEP + XER (8) | FEP + TAN (4) | MEM + XER (4) | MEM + XER (8) | MEM + TAN (4) | FEP + XER (4) | FEP + XER (8) | FEP + TAN (4) | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OmpK36 b | OmpK36 defective | |||||||||||
| All | N = 173 | N = 199 | ||||||||||
| MIC50 | ≤0.06 | ≤0.06 | 0.25 | 0.125 | ≤0.06 | 1 | 0.25 | 0.125 | 4 | 1 | 0.25 | 2 |
| MIC90 | 0.25 | ≤0.06 | 4 | 4 | 0.5 | 16 | 16 | 2 | 32 | 8 | 4 | 32 |
| No MBLs | N = 46 | N = 154 | ||||||||||
| MIC50 | ≤0.06 | ≤0.06 | ≤0.06 | 0.125 | ≤0.06 | 0.25 | 0.25 | 0.125 | 1 | 0.5 | 0.25 | 2 |
| MIC90 | 0.125 | ≤0.06 | 0.5 | 0.25 | 0.125 | 2 | 4 | 0.5 | 16 | 4 | 1 | 8 |
| KPC | N = 36 | N = 118 | ||||||||||
| MIC50 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | ≤0.06 | 0.25 | 0.25 | 0.125 | 1 | 0.5 | 0.25 | 2 |
| MIC90 | ≤0.06 | ≤0.06 | 0.125 | 0.25 | 0.125 | 1 | 8 | 0.5 | 16 | 4 | 1 | 8 |
| OXA-48-like | N = 10 | N = 31 | ||||||||||
| MIC50 | ≤0.06 | ≤0.06 | 0.25 | 0.125 | ≤0.06 | 0.25 | 0.125 | ≤0.06 | 4 | 0.5 | 0.25 | 2 |
| MIC90 | 0.125 | ≤0.06 | 4 | 0.5 | 0.125 | 4 | 0.25 | 0.25 | 8 | 2 | 0.5 | 8 |
| All MBL | N = 117 | N = 45 | ||||||||||
| MIC50 | ≤0.06 | ≤0.06 | 0.5 | 0.25 | ≤0.06 | 1 | 4 | 1 | 16 | 4 | 1 | 32 |
| MIC90 | 0.25 | 0.125 | 2 | 4 | 1 | 16 | 64 | 8 | >64 | 64 | 16 | >64 |
| NDM | N = 104 | N = 29 | ||||||||||
| MIC50 | 0.05 | 0.05 | 0.5 | 0.25 | 0.05 | 2 | 8 | 2 | 32 | 8 | 2 | 32 |
| MIC90 | 0.25 | 0.125 | 4 | 4 | 1 | 16 | 64 | 16 | >64 | >64 | 16 | >64 |
| VIM | N = 13 | N = 13 | ||||||||||
| MIC50 | ≤0.06 | ≤0.06 | ≤0.06 | 0.125 | ≤0.06 | 0.5 | 2 | 0.25 | 8 | 2 | 0.125 | 16 |
| MIC90 | ≤0.06 | ≤0.06 | 0.125 | 0.5 | ≤0.06 | 1 | 8 | 1 | 32 | 8 | 1 | 32 |
a
FEP, cefepime; MEM, meropenem; TAN, taniborbactam; XER, xeruborbactam.
b
OmpK36 was considered defective if frameshift, nonsense mutations, large insertions, a duplication of two amino acids, Gly134Asp135 (GD repeat) located within the L3 internal loop resulting in the constriction of the channel, or reduced expression due to insertions in the promoter region have been identified.