Table 3.

Effect of VISPO Topical Administration on Different Hair Parameters

	VISPO (n=18)	Placebo (n=19)	p-value (VISPO vs Placebo)
Hair comb test score
Baseline	20.28±7.32	18.94±9.93	0.650‡
Week 8	17.83±5.59	21.28±8.32	0.007§**
Week 16	15.78±6.41	22.94±8.69	0.008‡**
p-value (Baseline vs Week 8)	0.044†*	0.091†
p-value (Baseline vs Week 16)	0.029#*	0.018#*
Hair pull test score
Baseline	8.53±0.44	8.47±0.40	0.693‡
Week 8	7.33±0.64	8.56±0.34	<0.001§***
Week 16	6.78±0.55	8.58±0.35	<0.001§***
p-value (Baseline vs Week 8)	<0.001†***	0.437†
p-value (Baseline vs Week 16)	<0.001†***	0.362†
Hair density (Hairs/cm2)
Baseline	205.67±34.34	230.22±47.15	0.084‡
Week 8	214.11±35.48	222.94±49.96	0.545‡
Week 16	221.33±37.61	221.83±45.90	<0.001§***
p-value (Baseline vs Week 8)	<0.001#***	0.007#**
p-value (Baseline vs Week 16)	0.0016†**	0.044†*
Hair thickness (µm)
Baseline	16.50±4.40	16.61±3.88	0.936‡
Week 8	17.17±3.38	16.17±3.03	0.357‡
Week 16	17.44±3.67	16.56±3.40	0.456‡
p-value (Baseline vs Week 8)	0.378#	0.606#
p-value (Baseline vs Week 16)	0.420#	0.945#
Anagen/Telogen ratio
Baseline	3.10±0.95	3.25±0.89	0.631‡
Week 8	2.96±0.81	2.97±0.76	0.936§
Week 16	3.10±0.87	2.74±0.95	0.193§
p-value (Baseline vs Week 8)	0.323†	0.202†
p-value (Baseline vs Week 16)	0.886†	0.049†*

Notes: Values are mean±standard deviation (SD). ^#Paired t-test; ^‡Independent t-test; ^†Wilcoxon signed-rank test; ^§Mann–Whitney U-test. *p<0.05, **p<0.01 and ***p<0.001.