Table 1.
Clinical and pathological characteristics of different arthritis models in mice
| Arthritis model | |||
| Characteristics | Collagen-induced arthritis | K/B×N arthritis | G6PI-induced arthritis |
| Arthritogenic antigen | Cartilage specific (CII) | Systemic (G6PI) | Systemic (G6PI) |
| Susceptible strain | DBA/1 | KRN TCR transgenic × NOD F1 mice | DBA/1 |
| Arthritis induction | CII immunization and boost | Spontaneous | G6PI immunization |
| Pathogenic cells and effector mechanisms | |||
| T cells | ? | Induction phase | Induction and effector phases |
| Antibodies | Necessary and sufficient | Necessary and sufficient | Necessary |
| FcγRI or FcγRIII necessary | + | + | + |
| FcγRII | + | + or - in different studies | + |
| C5 | + | + | + |
| Mast cells | Uncertain | + | Unknown |
| Neutrophils | + | + | Unknown |
| Macrophages | Uncertain | Unknown | Unknown |
| TNF-α | + | (±) | + |
| IL-1 | + | + | Unknown |
| IL-6 | + | + | Unknown |
| Spontaneous remission | + | - | + |
CII, type II collagen; G6PI, glucose-6-phosphate isomerase; TNF, tumor necrosis factor.