Table 4.

Biological agents in the treatment of generalized pustular psoriasis.

Biological Agent	Dosage	Reference
Etanercept	50 mg of etanercept twice weekly subcutaneously	[94]
Infliximab	5 mg/kg body weight is administered on week 0, 2, 6, and then regularly every 8 weeks	[95]
Adalimumab	Dose of 80 mg is given s.c. in adults, and after the second week, a dose of 40 mg is given s.c. every 2 weeks. If the efficacy is insufficient, the dose may be increased to 80 mg/administration	[89]
Brodalumab	s.c. injections of 210 mg at weeks 0, 1, 2 and then every 2 weeks thereafter	[89,96]
Secukinumab	Weekly s.c. injections of 300 mg on weeks 0, 1, 2, 3, and 4, and then every 4 weeks thereafter (may be decreased to 150 mg)	[89]
Ixekizumab	s.c. injections of 160 mg at week 0, followed by 80 mg at weeks 2, 4, 6, 8, 10, and 12, then 80 mg every 4 weeks thereafter	[89]
Guselkumab	100 mg dose subcutaneously on weeks 0 and 4, followed by 100 mg every 8 weeks	[97]
Risankizumab	150 mg subcutaneously plus two additional samples at weeks 4 and 16	[98]
Anakinra	100 mg daily subcutaneously	[99,100]
Canakinumab	150 mg subcutaneously per month	[100]
Gevokizumab	60 mg subcutaneously every 4 weeks for a total of three injections (12 weeks)	[101]
Spesolimab	Single intravenous dose of 10 mg/kg	[102]