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Effect of human serum on pomotrelvir antiviral activity in the SARS-CoV-2 NLuc assay
| Human serum concentration | EC50 (nM) | Fold | EC90 (nM) | Fold |
|---|---|---|---|---|
| 0% human serum + (10% FBS) | 9.9 | − | 35 | − |
| 5% human serum + (10% FBS) | 16.6 | 1.7 | 96.2 | 2.8 |
| 10% human serum + (10% FBS) | 23.8 | 2.4 | 118.9 | 3.4 |
| 20% human serum + (10% FBS) | 53 | 5.3 | 125.9 | 3.6 |
