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. 2023 Nov 3;15(21):5282. doi: 10.3390/cancers15215282

Figure 5.

Figure 5

SYT1 overexpression downregulated the expressions of EMT-associated Slug and Vimentin in CRC xenograft metastasis nude mice model in vivo. (A,B) Immunostaining for SYT1, Slug, and Vimentin in lung (A) and liver (B) tissues of the control and SYT1 overexpression groups mice metastasis model. Scale bar, 50 μm. (C,D) The protein levels of Slug and Vimentin in liver and lung tissues of the control and SYT1 overexpression groups mice metastasis model detected by Western blot assays. (E) Gross images of tumors in situ of the control and SYT1 overexpression groups mice. (F) Immunostaining for Slug and Vimentin in tumors in situ of the control and SYT1 overexpression groups mice. Scale bar, 50 μm. (G) The protein levels of Slug and Vimentin in tumors in situ of SYT1 overexpression and the control groups detected by western blot assays. Tubulin or GAPDH was used as the loading control; * p < 0.05, ** p < 0.01, and *** p < 0.001. The uncropped bolts are shown in Supplementary Materials Figure S2.