Skip to main content
. 2023 Nov 6;28(21):7444. doi: 10.3390/molecules28217444

Table 3.

Information about the anti-inflammatory activity of essential oil and extracts of M. piperita.

Table Type of a Preparation,
Doses Tested		 Pharmacological Mechanisms of Action Values Reference
Carrageenan-induced paw edema test Essential oil, oral administration 30 min before introduction of carrageenan, 2, 20, and 200 μL/kg,
vehicle (isosaline NaCl 0.9%), and sodium diclofenac (50 mg/kg, orally) as the reference drug		 Reducing the paw edema induced using carrageenan injection in mice The levels of edema inhibition,12.27 ± 3.94% and 9.29 ± 3.94%, at 200 and 20 μL/kg, respectively, were comparable to the level observed using sodium diclofenac (11.43 ± 6.07%) [60]
Circular excision wound model in rats followed by histological examination The cream prepared from the essential oil (0.5% w/w) Decreasing in unhealed wound area Significant decrease in unhealed wound area between the 6th (1.67 ± 0.14 mm2) and 9th (0.49 ± 0.22 mm2) day of treatment in comparison with the vehicle and madecassol on 6th day (2.32 ± 0.77 mm2 and 2.23 ± 0.35 mm2, respectively)
Murine macrophage cell line RAW 264.7 stimulated with LPS The ethanolic extract of M. piperita, 25, 50, and 100 µg/mL Reducing the LPS-induced production of NO, TNF-a, and IL-6 compared with untreated control Reducing NO secretion in a concentration-dependent manner by 7.06, 18.85, and 41.88%, respectively. Suppression of TNF-a secretion by 20.71, 34.74, and 42.95%.
Reducing IL-6 levels by 27.00, 43.71, and 51.85%. Inhibition
of PGE2 production.		 [12]
PBMCs Essential oil,
0.01 µL/mL		 Reducing IL-4 production depends on cultivar and place of growing. [102]
5-LOX inhibition assay Essential oil 5-LOX inhibition IC50 were 0.08 and 0.03 μL/mL depending on the cultivar [80]
Activating antioxidant enzymes, the survival of peritoneal macrophage stimulated with lipopolysaccharide The hydroalcoholic leaf extract of M. piperita grown in Brazil Activating superoxide dismutase and glutathione peroxidase. Lowering the levels of H2O2. The survival was observed at the lower concentrations of the extract (1–30 µg/mL), while higher concentrations of the extract did decrease viability in the absence of lipopolysaccharides. No data [85]