TABLE 1.
Gastric lesions and H. felis colonization levels in WT (B6129F1) and iNOS−/− micea
| Genotype | Infection | Sexg (no.) | Score for finding inh:
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| Corpus
|
Antrum
|
||||||||
| Inflammation | Hyperplasia | Metaplasia | Atrophy | Inflammation | Hyperplasia | H. felis colonization | |||
| B6129F1 | None (control) | M (10)b | 0.25 (0-2) | 0 (0-3) | 0 (0-4) | 0 (0-3) | 1 (0-1) | 1 (0-1) | 0 (0) |
| F (10)b | 0.75 (0-1) | 0 (0-1) | 1 (0-3) | 0.5 (0-1) | 1 (1-3) | 1 (0-2) | 0 (0) | ||
| iNOS−/− | None (control) | M (11)b | 0.5 (0-3.5) | 1 (0-2) | 0 (0-2) | 0 (0-4) | 0 (0-4) | 1 (0-4) | 0 (0) |
| F (6) | 0.75 (0.5-1) | 0.5 (0-1) | 0 (0-1) | 0 (0) | 1 (0-1) | 1 (0-1) | 0 (0) | ||
| B6129F1 | H. felis | M (10) | 2.25 (0.5-4)e | 2 (1-4)c,e | 1.5 (0-4)d,e | 1 (0-4)c | 2 (1-2)c | 3 (1-4) | 4 (0-4)d,f |
| F (9) | 3.5 (2-3.5)e | 4 (1-4)e | 4 (0-4)e | 4 (1-4)e | 3 (1-3)e | 3 (2-4) | 0 (0-4)e | ||
| iNOS−/− | H. felis | M (9) | 1 (0.5-2.5) | 1 (1-2) | 0 (0-2) | 1 (0-2) | 2 (1-2) | 2 (1-3) | 4 (4)d |
| F (8) | 2 (0.5-3) | 2 (0-4) | 0 (0-1) | 2 (0-2) | 2 (0-2) | 2 (1-3) | 4 (0-4) | ||
a
See Results for specific P values.
b
This control group included one mouse with a high score in at least one parameter.
c
Significant influence of gender at a P of <0.05.
d
Trend for influence of gender at a P of <0.10.
e
Significant influence of genotype (iNOS−/− vs WT) at a P of <0.05.
f
Trend for influence of genotype (iNOS−/− vs WT) at a P of <0.10.
g
M, male; F, female.
h
Values presented are median scores (with ranges in parentheses). See Materials and Methods for a description of the scoring technique.