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. 2023 Nov 7;11(11):e006885. doi: 10.1136/jitc-2023-006885

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Transcriptomic characterization of the papillary renal cell carcinoma tumor microenvironment subtypes defined by IHC. (A) Volcano plot representing the messenger RNAs differential-expression analysis (=32,378 genes) from DESeq2, between the two groups identified from IHC in the AXIPAP trial cohort (n=30). Under the condition of log2 (fold-change) >2 and p adjusted <0.01, five differentially overexpressed genes were identified between the two groups (red circle). (B) Kaplan-Meier survival curves (overall survival (OS)) according to subgroups with a “high transcriptomic signature” and “low transcriptomic signature”, defined as a median of the five significant differentially overexpressed genes. IHC, immunohistochemistry.