Table 1.

Dose–response annotated activities of C15:0 (FA15), rapamycin, metformin, acarbose, and omega-3 (eicosapentaenoic acid, EPA, as previously published [25]) among 148 biomarkers and 12 primary human cell systems mimicking various disease states. Biomarker activities were annotated when 2 or more consecutive concentrations changed in the same direction relative to vehicle controls, were outside of the significance envelope and had at least one concentration with an effect size > 20% (|log10 ratio| > 0.1).

BioMAP Phenotypic Cell Profiles	Dose-Dependent Activities on Clinically Relevant Biomarkers
	C15:0 (FA15)	Rapamycin	Metformin	Acarbose	Omega-3 (EPA) [25]
Dose ranges	1.9–50 µM	0.3–9 µM	190–5000 µM	1.1–30 µM	1.9–17 µM
Dietary supplement (DS) or prescription drug (Rx) ingredient	DS	Rx	Rx	Rx	DS
Total number (%) of systems with dose-dependent activities	10 (83%)	12 (100%)	7 (58%)	3 (25%)	4 (33%)
Total number of biomarkers with dose-dependent changes	36	32	17	5	7