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A quantitative computer-assisted semiautomated method170 of measuring brain parenchymal fraction, a normalized measure of whole brain volume. Source images and processing of images is shown. The upper panel is the raw 2D T1-weighted noncontrast axial series. The middle panel is the same images after masking (removal) of extracranial tissue. The lower panel shows segmented images after thresholding separates the parenchyma (black) and CSF (white) into two compartments.
