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. 2023 Nov 2;24(21):15905. doi: 10.3390/ijms242115905

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of hypophosphatasia (HPP) on muscle fiber morphology and type. (A) Hematoxylin and eosin staining of gastrocnemius muscles from wildtype (WT) (n = 5) and HPP (n = 4) mice reveal normal muscle fiber structure. (B) HPP mice (cyan) had a significantly decreased proportion of embryonic MyHC-expressing muscle fibers compared to WT (red) (*, p ≤ 0.05; n = 3–4/group), with both (C) significantly fewer type I (or slow) muscle fibers (**, p ≤ 0.01; n = 4/group) and (D) significantly more type II (or fast) muscle fibers (**, p ≤ 0.01; n = 4/group). (E) As a percentage of the total muscle fibers, there were significantly fewer NADH-positive fibers in the HPP mice (*, p ≤ 0.05; n = 4/group), (F) but there was no significant difference in the percent of SDH-positive fibers between the groups (p = 0.087, n = 4/group). Independent t-tests assessed mean differences between WT and HPP genotypes.