FIG. 1.

Parameters of interest in the noninvasive diagnosis of brain tumors. Alteration of the blood-brain barrier and the extent of peritumoral edema are detected by MRI. Signs of increased cell proliferation can be observed by means of multi-tracer PET imaging using [¹⁸F]FDG, [¹¹C]MET, and [¹⁸F]FLT as specific tracers for glucose consumption, amino acid transport and DNA synthesis, respectively. Secondary phenomena, such as inactivation of ipsilateral cortical cerebral glucose metabolism, may be observed ([¹⁸F]FDG) and are of prognostic relevance. Gd = gadolinium. Reproduced with permission from Jacobs AH. PET in gliomas. In: Neuroonkologie (Schlegel U, Weller M, Westphal M, eds), pp 72–76. Copyright © 2003, Thieme-Verlag. All rights reserved.¹⁸⁶