Table 1.
Baseline characteristics of the patients
| Patient | Age (years) | Sex | Diagnosis | APACHE II | SOFA | PaO2/FiO2 (mmHg) | pH | Bicarbonate (mEq/L) | PEEP (cmH2O) | Crs (ml/cmH2O) | LIP (cmH2O) | Vasopressors/inotropesa | Outcome (S/NS) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 55 | M | Hepatic lobectomy | 14 | 13 | 144 | 7.38 | 25.4 | 10 | 51 | 10 | NA 0.08 | S |
| Dbt 3.3 | |||||||||||||
| 2 | 23 | F | Peritonitis | 20 | 10 | 388 | 7.36 | 23.5 | 8 | 32 | 10 | NA 0.12 | S |
| 3 | 32 | M | Mucormycosis and sepsis | 7 | 7 | 282 | 7.42 | 21.5 | 6 | 60 | 6 | NA 0.09 | S |
| 4 | 68 | F | Acute pancreatitis | 9 | 13 | 208 | 7.38 | 20.4 | 10 | 40 | NL | NA 0.2 | NS |
| 5 | 59 | F | Pneumonia and sepsis | 16 | 8 | 197 | 7.28 | 25.5 | 10 | 55 | NL | NA 0.03; Dp 6.8; Dbt 3.4 |
S |
| 6 | 68 | M | Thoracic trauma | 14 | 10 | 289 | 7.36 | 21.6 | 4 | 37 | 13 | NA 0.05 | S |
| 7 | 72 | M | Sepsis | 17 | 9 | 263 | 7.25 | 13.8 | 4 | 50 | 8 | Dbt 5.4 | S |
| 8 | 86 | M | Pneumonia and sepsis | 14 | 12 | 150 | 7.37 | 20.3 | 12 | 27 | 13 | NA 0.02 | NS |
APACHE, Acute Physiology and Chronic Health Evaluation; Crs, Respiratory system compliance; Dbt, dobutamine; Dp, dopamine; LIP, lower inflection point; NE, norepinephrine (noradrenaline); NL, no LIP found; NS, not significant; PEEP, positive end-expiratory pressure; S, significant; SOFA, Sepsis-related Organ Failure Assessment. aDoses are in μg kg-1 min-1.