Table 4.

Overall performance metrics for classification of benign vs. malignant disease.

Predictor	Published Cutoff	Menopausal Status	n=	AUC (95% CI)	Sensitivity (95% CI)	Specificity (95% CI)	PPV (95% CI)	NPV (95% CI)
Multimarker Panel		combined	334	0.98 (0.97–1.00)	0.95 (0.91–0.98)	0.95 (0.90–0.98)	0.95 (0.90–0.98)	0.95 (0.91–0.98)
	n/a	pre	115	0.95 (0.91–1.00)	0.81 (0.64–0.93)	0.98 (0.92–1.00)	0.93 (0.77–0.99)	0.93 (0.86–0.97)
		post	219	0.99 (0.98–1.00)	0.99 (0.95–1.00)	0.92 (0.84–0.97)	0.95 (0.90–0.98)	0.98 (0.92–1.00)
CA125		combined	334	0.95 (0.93–0.97)	0.94 (0.89–0.97)	0.82 (0.75–0.87)	0.83 (0.77–0.88)	0.93 (0.88–0.97)
	35	pre	115	0.92 (0.86–0.98)	0.91 (0.75–0.98)	0.80 (0.69–0.88)	0.63 (0.48–0.77)	0.96 (0.88–0.99)
		post	219	0.96 (0.93–0.98)	0.95 (0.89–0.98)	0.84 (0.75–0.91)	0.90 (0.84–0.94)	0.91 (0.83–0.96)
ROMA%		combined	333	0.97 (0.95–0.99)	0.93 (0.88–0.96)	0.92 (0.87–0.96)	0.92 (0.87–0.96)	0.93 (0.88–0.96)
	13.1	pre	115	0.93 (0.87–0.99)	0.81 (0.64–0.93)	0.95 (0.88–0.99)	0.87 (0.69–0.96)	0.93 (0.85–0.97)
	27.7	post	218	0.98 (0.97–1.00)	0.96 (0.90–0.98)	0.90 (0.81–0.95)	0.93 (0.88–0.97)	0.93 (0.85–0.97)
RMI2		combined	169	0.95 (0.93–0.98)	0.96 (0.88–1.00)	0.75 (0.66–0.83)	0.66 (0.55–0.76)	0.98 (0.92–1.00)
	200	pre	66	0.98 (0.94–1.00)	0.89 (0.52–1.00)	0.86 (0.74–0.94)	0.50 (0.25–0.75)	0.98 (0.89–1.00)
		post	103	0.94 (0.89–0.98)	0.98 (0.89–1.00)	0.64 (0.50–0.77)	0.70 (0.57–0.80)	0.97 (0.86–1.00)