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. 2023 Oct 27;24(21):15658. doi: 10.3390/ijms242115658

Figure 7.

Figure 7

Volasertib combined with bempedoic acid suppressed expressions of cell−cycle−related and DNL−related genes. (A,D,G) NCI-H460 cells, (B,E,H) HepG2 cells, and (C,F,I) MCF7 cells were treated with volasertib and/or ACLY inhibitor bempedoic acid by corresponding 1/2 IC50 dose concentration for 24 h. Expressions of genes were evaluated via real-time PCR. (J) NCI-H460, (K) HepG2, and (L) MCF7 cells were treated with volasertib and/or bempedoic acid for 24 h, and relative protein expression of UBE2C was determined by Western blotting. ns—no significance, * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001 (two-way ANOVA) indicate significant differences between fold induction.