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. 2023 Nov 2;24(21):15910. doi: 10.3390/ijms242115910

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Altered gene expression of the MDM2, PTEN, and p53 tumor-suppressor-oncoprotein network. Relative gene expression analysis of MDM2, PTEN, and p53 after treatment with DMAS and shikonin for 24 h in MFS cells. Untreated control cells served as reference value (ratio = 1; mean ± SD, n = 6, measured in triplicate). Statistical significances to the untreated controls are defined as follows: * p < 0.05; *** p < 0.001. Statistical significances between the two cell lines MUG-Myx2a and MUG-Myx2b were marked by means of ^# p < 0.05; ^## p < 0.01; ^### p < 0.001.