Table 1.
Patient number/sex | Age (years) | Length (cm) | Weight (kg) | Diagnosis | Propofol infusiona (mg/kg per hour) | Duration of infusionb (hours) | Opioidsc |
1/M | 59 | 180 | 86 | Thoracic aorta dissection | 1.63 | 31 | Oxycodon 10 mg |
2/M | 53 | 180 | 130 | Acute myocardial infarction | 0.62 | 11 | Fentanyl 0.100 mg/hour |
3/M | 47 | 173 | 68 | Pneumonia and sepsis (streptococcal pneumonia) | 1.18 | 13 | Oxycodon 3 mg |
4/F | 47 | 170 | 68 | Multitrauma (renal rupture, pelvic fracture) | 1.76 | 20 | Oxycodon 10 mg |
5/M | 61 | 169 | 96 | Ruptured abdominal aortic aneurysm | 2.08 | 19 | Fentanyl 0.100 mg/hour |
6/M | 76 | 174 | 73 | Acute myocardial infarction and peritonitis | 2.47 | 66 | Fentanyl 0.100 mg/hour |
7/F | 72 | 160 | 70 | Acute lung injury and status post-AVR+CABG | 1.71 | 10 | Oxycodon 5 mg |
8/M | 66 | 176 | 90 | Acute lung injury and status post-CABG | 4.44 | 46 | Fentanyl 0.150 mg/hour |
9/M | 68 | 162 | 79 | Wound infection post-CABG | 3.04 | 112 | Oxycodon 35 mg |
10/M | 64 | 164 | 65 | Peritonitis and septic shock | 1.85 | 13 | Fentanyl 0.200 mg |
11/F | 70 | 162 | 89 | Acute myocarial infarction and status post-CABG | 0.67 | 16 | Oxacodon 5 mg |
12/M | 83 | 167 | 65 | Peritonitis | 2.15 | 19 | Fentanyl 0.075 mg |
13/M | 72 | 176 | 96 | Sternal dehiscence post-CABG | 1.46 | 14 | Oxycodon 36 mg |
14/M | 76 | 183 | 77 | Acute myocarial infarction and pulmonary haemorrhage | 1.04 | 18 | Oxycodon 10 mg |
15/F | 71 | 162 | 58 | Wound infection post-CABG+AVR | 1.72 | 19 | Fentanyl 0.150 mg, oxycodon 29 mg |
16/M | 77 | 167 | 73 | Acute respiratory distress syndrome | 2.74 | 69 | Fentanyl 0.825 mg, oxycodon 15 mg |
17/F | 50 | 170 | 75 | Low cardiac output (status post-CABG) | 1.60 | 86 | Fentanyl 0.150 mg/hour |
18/F | 59 | 165 | 60 | Acute lung injury and septic shock | 1.67 | 12 | Oxycodon 3 mg |
19/M | 71 | 170 | 80 | Acute myocarial infarction and pulmonary oedema | 1.50 | 14 | Oxycodon 18 mg |
Mean | 65 | 170 | 79 | - | 1.91 | 31 | - |
SD | 11 | 7 | 16 | - | 0.88 | 29 | - |
aRate of propofol infusion at the time of measurements. bNumber of hours of continuous propofol infusion before measurements. cOpioid medication administered during the 12 hours before (total intravenous bolus) and/or during the measurements (infusion rate). AVR, aortic valve replacement; CABG, coronary artery bypass graft.