Scheme 1.
Reagents and conditions: (i) H2SO4, EtOH, N2, reflux, 8 h; (ii) dichlorodiphenylmethane, diphenyl ether, 175 °C, 30 min; (iii) 6a–6g, K2CO3, KI, DMF, 25 °C, 24 h; (iv) H2, 10%Pd/C, THF/EtOH, 12 h; (v) Et3N, DCM, N2, 0 °C, 5 h.
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