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. 2023 Oct 27;12(21):2535. doi: 10.3390/cells12212535

Figure 3.

Figure 3

IL-1β stimulates co-cultures but not dopaminergic neuronal or microglia monocultures to release MCP-1, IL-6, and IL-8. (A) IL-6, (B) IL-8, and (C) MCP-1 levels in IL-1β stimulated dopaminergic neurons (DAN), microglia (MG), and co-culture (co-DAN-MG). Media samples were assayed with the Legendplex Human Inflammation Panel 1. DAN: n = 5 differentiations of 1–3 lines per differentiation experiment, MG: n = 2 differentiations of 3 lines each, and co-DAN-MG: n = 10 differentiations of 1–2 lines per differentiation experiment. Cell culture media were taken from three healthy controls: SFC086-03-03, SFC089-03-07, and SCF156-03-01. Mean ± SEM. Asterisks indicate significant difference between different cell models by one-way ANOVA followed by Tukey’s multiple comparisons test (* p < 0.05, ** p < 0.01, **** p < 0.0001).