Skip to main content
. 2023 Sep 4;15(17):4419. doi: 10.3390/cancers15174419

Figure 4.

Figure 4

Topology diagrams of the three domains for each of the 12 hALDHs of known structure. All three domains of hALDH18A1 are distinct, while all the other members have in common at least the topology of catalytic domain. hALDH3A1 and 3A2 have in addition a common topology of their cofactor binding domains. ALDH4A1 shares with the hALDH3Ai pair a quite common oligomerization domain. hALDH1/2, 5A1, and 9A1 have common topologies in all three domains, while hALDH4A1 and 7A1 might be the bridge between the 3Ai subgroup and the 1/2, 5A1, 9A1 subgroup.