Table 5.
Supportive and not-supportive clinical findings for likelihood of pulmonary sarcoidosis.
| Clinical Data | Supportive | Not Supportive |
|---|---|---|
| Demographics | African American | Age < 18 years; >80 years |
| Northern European | ||
| Medical history | Family history of sarcoidosis | |
| Non-smoker | ||
| History of unexplained fatigue and/or pain | ||
| Symptoms involving two or more organs | ||
| Specific combinations, e.g., lung and eyes; lung and skin | ||
| History of kidney stones | ||
| Extrapulmonary disease potentially related to sarcoidosis | Uveitis, erythema nodosum (small fiber), neuropathy, etc. | |
| Disease course | Rapid progressive (diffuse) lung disease (days to few week) +/− respiratory failure | |
| Laboratory results | Increased serum sACE | |
| Increased sIL-2R | ||
| Increased CTO | ||
| Lymphopenia | ||
| Increased serum calcium | ||
| Hypercalciuria | ||
| Decreased 25-hydroxyvitamin D/increased 1,25-hydroxyvitamin D | ||
| BAL findings | Lymphocytosis | |
| Increased CD4+/CD8+ ratio | ||
| Decreased CD103+CD4+/CD4+ ratio |
Definition of abbreviations: sACE, serum ACE; sIL-2R, soluble IL-2 receptor; CTO, chitotriosidase; BAL, bronchoalveolar lavage.