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Structures and activities of 6-substituted indole compounds against the AF9-DOT1L interaction.
| |||||
|---|---|---|---|---|---|
| Cpd # | R6 | IC50 (μM) or % Inhihition at 5 μM | Cpd # | R6 | IC50 (μM) or % Inhihition at 5 μM |
| 1 |
|
3.3 ± 0.2 | 9 |
|
17% |
| 3 |
|
2.8 ± 0.2 | 10 |
|
0% |
| 4 |
|
31% | 11 |
|
10% |
| 5 |
|
40% | 2 |
|
4.5 ± 0.01 |
| 6 |
|
14% | 12 |
|
2.9 ± 0.1 |
| 7 |
|
5.6% | 13 |
|
29% |
| 8 |
|
37% | 14 |
|
11% |
