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Structures and activities of 5-substituted indole compounds against the AF9-DOT1L interaction.
| |||||
|---|---|---|---|---|---|
| Cpd # | R5 | IC50 (μM) or % Inhihition at 5 μM | Cpd # | R5 | IC50 (μM) or % Inhihition at 5 μM |
| 15 |
|
3.6 ± 0.3 | 20 |
|
8% |
| 16 |
|
2.7 ± 0.2 | 21 |
|
0% |
| 17 |
|
52% | 22 |
|
>30 |
| 18 |
|
36% | 23 |
|
43% |
| 19 |
|
13% | |||
