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Structures and activities of 5-substituted benzothiophene compounds against the AF9-DOT1L interaction.
| ||
|---|---|---|
| Cpd # | R5 | IC50 (μM) or % Inhihition at 5 μM |
| 50 |
|
2.5 ± 0.2 |
| 51 |
|
31% |
| 52 |
|
0% |
| 53 |
|
23% |
| 54 |
|
33% |
| 55 |
|
45% |
| 56 |
|
24% |
