Table 2.

Summary of studies of dantrolene treatment of heat stroke in animals

Reference	Study type	Model	Numbers included	Dantrolene dose (mg/kg bw)	Improved parameters	Nonimproved parameters
[18]	Randomized controlled	Exercising rats	7	140	Cooling rate	-
		Nonexercising rats	7	140	-	Cooling rate
[19]	Randomized controlled	Nonexercising piglets	4	3	Cooling ratea	Cardivascular parameters
[16]	Randomized controlled	Nonexercising dogs	5	5	-	Cooling rate, haemodynamic parameters, pathological changes, clinical outcome

^aImprovement was reported with or without mannitol. bw, Body weight