Table 3.
Summary of studies of dantrolene pretreatment of heat stroke in animals
| Numbers included | |||||||
| Reference | Study type | Model | Dantrolene treatment arms | Control arms | Dantrolene dose (mg/kg bw) | Improved parameters | Nonimproved parameters |
| [20] | Randomized controlled | Exercising sheep | 6 | 6 | 1.5–3 | Body temperature, Severity of heat stroke signs, changes in serum enzymes and hormones, survivala | - |
| [18] | Randomized controlled | Exercising rats | 7 | 7 | 140 | - | Physical capacity |
| Nonexercising rats | 7 | 7 | 140 | Endurance in the heat | - | ||
aTrend only. bw, Body weight.