Table 2.

ROC analysis for predictors of the LAD Dmax > 10 Gy and LAD Dmean > 4 Gy.

LAD Dmax > 10 Gy	Cut-off Value	AUC	95%IC	p Value
Minimum distance from LAD to tangent fields	≤−0.11 cm	0.714	0.614–0.801	<0.0001
Lung Volume	≤1087.7 cc	0.626	0.553–0.695	0.002
Heart volume	>655.51 cc	0.660	0.497–0.799	0.07
LAD Dmean > 4 Gy	Cut-off Value	AUC	95%IC	p Value
Minimum distance from LAD to tangent fields	<0.49 cm	0.687	0.588–0.744	0.001
Breast separation	>16.1 cm	0.649	0.550–0.740	0.008
Heart volume	>652.6 cc	0.672	0.508–0.810	0.051
Lung volume	≤1190.6 cc	0.624	0.519–0.722	0.050

ROC comparison curves of variables predicting a LAD maximum dose > 10 Gy and a LAD mean dose > 4 are shown in Figure 2. The minimum distance of LAD from tangent open fields was the strongest predictor of both the LAD mean and maximum dose.