Table 1.

Comparison of options for stress ulcer prophylaxis

Characteristic	Sucralfate	Antacids	H2RAs	Esomeprazole	Lansoprazole	Omeprazole	Pantoprazole	Rabeprazole
Efficacy in elevating gastric pH		+	+	+++	+++	+++	+++	+++
Tolerability	+	+	+	+++	+++	+++	+++	+++
Use in organ failure							+
Low potential for drug interactions							+
Administration options
Oral				+	+	+	+	+
Intravenous			+	+		+	+
Nasogastric	+	+		+	+	+

H₂RAs, histamine H2 receptor antagonists.