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. 2023 Aug 8;109(5):669–683. doi: 10.1093/biolre/ioad093

Figure 2.

Figure 2

Granulosa-specific PXN knockout mice produce more pups when bred continuously to 26 weeks of age due to increased number of litters over time. (A) Schematic representation of litter appearance and size for each mouse in the study. (B) Cumulative number of offspring per female (n = 6 per group) from 12 to 26 weeks of age. (C) Total number of litters per female (n = 6 per group) from 12 to 26 weeks of age. (D) Average size of all litters produced by each female (n = 6 per group) between 12 and 26 weeks of age. (E) Number of oocytes counted in both ampullae during estrus at 28–30 weeks of age (n = 8 per group). (F) Number of days between delivery and subsequent pregnancy observed between 24 and 28 weeks of age in a separate cohort (CTRL:n = 5 litters by three mice; PXN-KO:n = 7 litters by three mice). Graphs represent averages and standard errors. ns, not significant. *P < 0.05, ***P < 0.001.