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. 2023 Aug 28;228(Suppl 7):S682–S690. doi: 10.1093/infdis/jiad345

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© 2023, The authors and His Majesty the King in Right of Canada, as represented by the Minister of Health, have joint ownership of copyright in this article.

This article contains public sector information licensed under the Open Government Licence v3.0 (http://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/).

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Figure 2. — Kinetics of vectorized MR191 variants in mice. Six-week-old female BALB/c mice (n = 4) were administered 1 × 10¹¹ vector genomes of (A) AAV6.2FF-MR191, (B) AAV6.2FF-MR191-GP_op, (C) AAV6.2FF-MR191-io2, or (D) AAV6.2FF-MR191-GP_HL. Human (A–C) or guinea pig (D) IgG levels in the plasma were monitored weekly via ELISA. Data from individual mice are plotted. Abbreviations: AAV, adeno-associated virus; ELISA, enzyme-linked immunosorbent assay; IgG, immunoglobulin G.