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. 2023 Aug 28;228(Suppl 7):S682–S690. doi: 10.1093/infdis/jiad345

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© 2023, The authors and His Majesty the King in Right of Canada, as represented by the Minister of Health, have joint ownership of copyright in this article.

This article contains public sector information licensed under the Open Government Licence v3.0 (http://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/).

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Figure 4. — AAV6.2FF-mediated expression of MR191 variants provides complete protection against MARV. Guinea pigs (n = 3/group) were administered 5 × 10¹² vector genomes of AAV6.2FF-MR191, AAV6.2FF-MR191-io2, AAV-MR191-GP_op, or AAV-MR191-GP_HL. All animals were challenged with 1000 LD₅₀ GPA-MARV on day 92 after AAV administration and monitored for survival (A) and weight loss (B). Data from individual animals are plotted in (B). Abbreviations: AAV, adeno-associated virus; GPA-MARV, guinea pig-adapted Marburg virus; LD₅₀, median lethal dose.