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. 2023 Jun 8;228(Suppl 7):S712–S720. doi: 10.1093/infdis/jiad207

Figure 2.

Figure 2.

Gross pathology and histopathology following BDBV challenge. A, Necrotizing hepatitis in 1 NHP that succumbed. B, BDBV GP-positive mononuclear cells (arrows) within the subcapsular sinus of the lymph node. C, Lack of significant BDBV immunolabeling in the lymph node of a surviving animal. D, Necrotizing hepatitis (arrows) seen in an NHP that succumbed. E, BDBV GP-positive hepatocytes (arrows) and mononuclear cells. F, Splenitis with lymphocytolysis (arrows). G, BDBV GP-positive mononuclear cells within germinal centers (arrow). H–K, Examination of a VSV-BDBV–treated survivor: (H) liver, no appreciable lesions; (I) liver, no appreciable immunolabeling; (J) spleen, no appreciable lesions; (K) spleen, no appreciable immunolabeling. B, D, E, G, H, and I, 40 × magnification. C, J, and K, 20 × magnification. F, 10 × magnification. Abbreviations: BDBV, Bundibugyo virus; GP, glycoprotein; NHP, nonhuman primate.