Figure 6.

Protection against lethal EBOV, SUDV, or BDBV challenge induced by the homologous vaccines or HPIV3/ΔF-HN/Trivalent in guinea pigs or ferrets. A, Survival. B, Disease scores. C, Changes in body weight. D, Viremia; horizontal line indicates limit of detection. n = 5 animals per group except n = 4 guinea pigs for HPIV3 group in EBOV challenge study. For survival, P values are indicated for comparisons against the respective vector-control group based on log-rank Mantel-Cox statistical analyses. Abbreviations: BDBV, Bundibugyo virus; EBOV, Ebola virus; HPIV3, human parainfluenza virus type 3; PFU, plaque-forming unit; SUDV, Sudan virus.