Table 1.
Baseline characteristics of patients included in the studies.
| Variables | Blumenstein et al., 20228 | Corcione et al., 202013 | Perlman et al.4 | Willson et al.14 | Mollmann et al.3 (PorticoTM DS) | Mollmann et al.3 (FlexNavTM DS) | Möllmann et al.15 | Raj R Makkar et al. |
|---|---|---|---|---|---|---|---|---|
| Sample size | 344 | 114 | 57 | 10 | 501 | 500 | 222 | 1034 |
| Study design | Nonrandomized cohort | Observational cohort | Observational cohort | Observational cohort | Observational cohort | Observational cohort | Prospective, nonrandomized, multicenter study | RCT |
| Age, years (Mean) | 82.92 | 82.4 | 80.8 | 82.4 | 81.7 | 82.3 | 83.0 | 83±7 |
| Female, n (%) | 206 (59.9) | 70 (61) | 47 (82.5) | 10 (100%) | 320 (63.70%) | 307 (61.40%) | 165 (74.32%) | 395 (52·7%) |
| NYHA Class III/IV | 290 | 85/1 | 43 | 8/0 | 295 / 32 | 293/18 | 166/ 9 | 229 (60·1%)/43 (11·3%) |
| STS score | – | – | 7.7±5.7 | 8.1 3.2 | 4.2±2.9 | 4.2±2.7 | 5.8±3.3 | 6·5 ±3·4 |
| Diabetes, n (%) | 120 | 21 | 20 | 5 | 176 | 182 | 69 | 143 (37·5%) |
| Hypertension, n (%) | 308 | 80 | 46 | – | 440 | 431 | – | 358 (94·0%) |
| Previous MI, n (%) | 37 | 10 | 10 | – | 68 | 61 | 26 | 55 (14·4%) |
| Previous stroke, n (%) | 31 | 2 | 7 | – | 53 | 38 | 18 | 29 (7·6%) |
| Previous peripheral artery disease, n (%) | 48 | – | 14 | 1 | 60 | 59 | 18 | 72 (18·9%) |
| Previous atrial fibrillation, n (%) | 135 | – | 20 | – | 246 | 238 | 85 | 125 (32·8%) |
| Mean AVA, cm2 | – | 0.6 | 0.7 | 0.62 | 0.71 | 0.72 | – | 0·68±0·17 |
| LVEF,% | 59.25 | 55 | 58.4 | 57.3 | – | – | >20 | 57·3 (11·5) |
| Moderate to severe mitral regurgitation, n | 5 | 50 | – | 5 | 1 | 1 | – | 78 (20·5%) |
| Mean Transaortic gradient, mmHg | 42.75 | 50 | 41.8 | 44.5 | 43.4 | 42.2 | 43.3 | 46·2 (11·2) |