Extended Data Fig. 4. Context locations within the mutational spectrum.

The RNA mutational spectrum contains 12 mutation types, for example C-to-T, shown here. The spectrum also captures the nucleotides surrounding each mutation. There are four potential upstream nucleotides and four potential downstream nucleotides. This figure shows the location of each of the 16 contexts within an example mutation type. For example, the leftmost bar represents C-to-T mutations in the ACA context while the second leftmost bar represents C-to-T mutations in the ACC context. The spectrum represented is from AGILE trial data on monlupiravir.