Extended Data Fig. 9. Two-day PHM alleviates the sensitivity of RVLM in SHRSPs to angeotensin II or valsartan.
a, Schematic representation of the experimental protocol. Pressor and depressor responses were analysed as in Fig. 2. b−e, Pressor (b,c) and depressor (d,e) responses in SHRSPs with and without 2-day PHM. (b,d) Representative trajectories of the blood pressure (top in each panel) and MAP (bottom in each panel). Arrows point to the time of the initiation of RVLM injection of Ang II (b) or valsartan (d). Right-angled scale bars, 1 min / 50 mm Hg. (c, e) MAP change caused by Ang II (c) or valsartan (e) injection [c: P = 0.0064. e: P = 0.0022. n = 4 rats for PHM (–); n = 3 rats for PHM (+)]. Data are presented as mean ± s.e.m. **P < 0.01; unpaired two-tailed Student’s t-test.