Fig. 2.

Levels of circulating proinflammatory cytokines and markers of metabolism at 27 months of age in male mice. Circulating levels of (A) IL-6, (B) TNF-α, (C) KC/GRO, (D) total triglyceride (TG), (E) free fatty acids (FFA), (F) total cholesterol (TC), (G) HDL-C, (H) LDL-C and VLDL-C, (I) insulin, (J) fibroblast growth factor-21 (FGF21), and (K) insulin like growth factor-1 (IGF1) (n = 10/group). Diets: CD—control, IKD—intermittent ketogenic, KD—ketogenic. ∗ p < 0.05, ∗  ∗ p < 0.01, ∗  ∗  ∗ p < 0.001 based on one-way ANOVA followed with the Tukey’s multiple comparisons test or the Brown-Forsythe and Welch ANOVAs followed with the Dunnett’s T3 multiple comparisons test where appropriate