Fig. 4.

Behavior tests of cognitive function in male mice at 23 and 26 months of age. (A) Y maze spontaneous alternation test: percent of alternations. (B) Novel object test: percent time exploring the novel object. (C) Barnes maze test: latency to the target hole in the probe trial (lower the better). (D) Barnes maze test: time spent in the target quadrant in the probe trial (higher the better). (E) Composite of cognitive tests. 23 months: n = 17–18; 26 months: n = 14–17/group. Diets: CD—control, IKD—intermittent ketogenic, KD—ketogenic. Data were analyzed by repeated measures two-way ANOVA followed with the Tukey’s or the Bonferroni multiple comparisons tests. ∗ p < 0.05, ∗  ∗  ∗  ∗ p < 0.0001. Different letters of a and b denote difference (p < 0.05) between ages