TABLE 5.

Stepwise linear regression results for eGFR at 60 months post‐transplant (N = 106).

Variable	% With characteristic if categorical/Median [interquartile range] if continuous	Univariable p value	Multivariable p value	Model a Coeff ± SE
Group A	33.0% (35/106)	0.46
Group B	30.2% (32/106)	0.13
Group C	36.8% (39/106)	0.03	(√) 0.01	−9.360 ± 3.553
Recipient age (years)	48.3 [34.6–58.6]	0.10
Male recipient	67.9% (72/106)	0.41
African–American recipient	17.0% (18/106)	0.03
Hispanic recipient	38.7% (41/106)	0.45
Recipient BMI	25.2 [22.4–28.1]	0.80
Pretransplant CVD	17.0% (18/106)	0.47
Pretransplant diabetes	12.3% (13/106)	0.64
DD recipient	81.1% (86/106)	0.64
Nonstandard DD recipient	13.2% (14/106)	0.08
Donor age (years)	36.5 [23.0–47.0]	0.000001	(√) <0.000001	−0.770 ± 0.126
# HLA mismatches	3.5 [3.0–4.0]	0.31
First BPAR ≤60 months	16.0% (17/106)	0.001	(√) 0.00008	−19.212 ± 4.672
NODAT ≤60 months	26.4% (28/106)	0.41
Rank {Avg CNI level: 0–60 months}	0.51 [0.26–0.76]	0.76
Multivariable linear regression model for eGFR at 60 mo post‐transplant (N = 106), considering the effect of rank {avg CNI level during 0–60 months}
Variable	Multivariable p value	Model b Coeff ± SE
Group C	0.01	−9.373 ± 3.573
Donor age (years)	<0.000001	−0.770 ± 0.126
First BPAR ≤60 months	0.0001	−19.135 ± 4.776
Rank {Avg CNI level: 0–60 months}	0.93	0.528 ± 6.050

Note: (√) Represents selection into the multivariable linear regression model.

Abbreviations: Avg, average; BMI, body mass index; BPAR, biopsy‐proven acute rejection; CNI, calcineurin inhibitor; Coeff, coefficient; CVD, cardiovascular disease; DD, deceased donor; eGFR, estimated glomerular filtration rate; HLA, human leukocyte antigen; NODAT, new onset diabetes after transplant.

^a The 3 variables selected into the multivariable model were defined as follows: group C = {1 if recipient was randomized into group C, 0 otherwise}; donor age (years) (continuous variable); and first BPAR ≤60 months = {1 if the patient experienced a first BPAR during the first 60 months post‐transplant, 0 otherwise}. The estimated intercept term ± SE for the multivariable model was: 91.508 ± 5.108, and the coefficient of multiple determination was 0.37.

^b The 4 variables included in this multivariable model were defined as follows: group C = {1 if recipient was randomized into group C, 0 otherwise}; donor age (years) (continuous variable); first BPAR ≤60 months ={1 if the patient experienced a first BPAR during the first 60 months post‐transplant, 0 otherwise}; and rank {Avg CNI level: 0–60 months} = rank of the average CNI trough level during 0–60 months post‐transplant. The estimated intercept term ± SE for the multivariable model was: 91.254 ± 5.898, and the coefficient of multiple determination was 0.37.