TABLE 6.

Stepwise linear regression results for eGFR at 120 months post‐transplant (N = 71).

Variable	% With characteristic if categorical/Median [interquartile range] if continuous	Univariable p value	Multivariable p value	Model a Coeff ± SE
Group A	26.8% (19/71)	0.18
Group B	31.0% (22/71)	0.16
Group C	42.3% (30/71)	0.01	(√) 0.002	−14.394 ± 4.449
Recipient age (years)	48.4 [34.5–58.4]	0.51
Male recipient	62.0% (44/71)	0.17
African‐American recipient	12.7% (9/71)	0.50
Hispanic recipient	40.8% (29/71)	0.58
Recipient BMI	25.1 [22.4–28.1]	0.94
Pretransplant CVD	14.1% (10/71)	0.73
Pretransplant diabetes	8.5% (6/71)	0.51
DD recipient	77.5% (55/71)	0.51
Nonstandard DD recipient	14.1% (10/71)	0.05
Donor age (years)	36.0 [22.0–46.0]	0.002	(√) 0.000003	−0.869 ± 0.170
# HLA mismatches	4.0 [3.0–5.0]	0.53
First BPAR ≤120 months	14.1% (10/71)	0.001	(√)<0.000001	−35.217 ± 6.504
NODAT ≤120 months	35.2% (25/71)	0.08
Rank {Avg CNI level: 0–120 months}	0.52 [0.26–0.76]	0.82
Multivariable linear regression model for eGFR at 120 months post‐transplant (N = 71), considering the effect of rank {Avg CNI Level during 0–120 months}
Variable	Multivariable p value	Model b Coeff ± SE
Group C	0.002	−14.506 ± 4.500
Donor age (years)	0.000003	−0.872 ± 0.172
First BPAR ≤120 months	0.000001	−35.234 ± 6.550
Rank {Avg CNI level: 0–120 months}	0.79	2.080 ± 7.707

Note: (√) Represents selection into the multivariable linear regression model.

Abbreviations: Avg, average; BMI, body mass index; BPAR, biopsy‐proven acute rejection; CNI, calcineurin inhibitor; Coeff, coefficient; CVD, cardiovascular disease; DD, deceased donor; eGFR, estimated glomerular filtration rate; HLA, human leukocyte antigen; NODAT, new onset diabetes after transplant.

^a The 3 variables selected into the multivariable model were defined as follows: group C = {1 if Recipient was Randomized into Group C, 0 otherwise}; donor age (years) (continuous variable); and first BPAR ≤120 months = {1 if the patient experienced a first BPAR during the first 120 months post‐transplant, 0 otherwise}. The estimated intercept term ±SE for the multivariable model was: 100.388 ± 6.774, and the coefficient of multiple determination was 0.46.

^b The 4 variables included in this multivariable model were defined as follows: group C = {1 if recipient was randomized into group C, 0 otherwise}; donor age (years) (continuous variable); first BPAR ≤120 months = {1 if the patient experienced a first BPAR during the first 120 months post‐transplant, 0 otherwise}; and rank {Avg CNI level: 0–120 months} = rank of the average CNI trough level during 0–120 months post‐transplant. The estimated intercept term ±SE for the multivariable model was: 99.457 ± 7.644, and the coefficient of multiple determination was 0.46.