TABLE 7.
Stepwise linear regression results for eGFR at 180 months post‐transplant (N = 42).
| Variable | % With characteristic if categorical/Median [interquartile range] if continuous | Univariable p value | Multivariable p value | Model a Coeff ± SE |
|---|---|---|---|---|
| Group A | 31.0% (13/42) | 0.85 | ||
| Group B | 35.7% (15/42) | 0.93 | ||
| Group C | 33.3% (14/42) | 0.93 | ||
| Recipient age (years) | 46.2 [33.0–55.7] | 0.09 | ||
| Male recipient | 64.3% (27/42) | 0.33 | ||
| African‐American recipient | 14.3% (6/42) | 0.95 | ||
| Hispanic recipient | 47.6% (20/42) | 0.36 | ||
| Recipient BMI | 25.1 [22.4–28.1] | 0.90 | ||
| Pretransplant CVD | 11.9% (5/42) | 0.51 | ||
| Pretransplant diabetes | 4.8% (2/42) | 0.53 | ||
| DD recipient | 78.6% (33/42) | 0.41 | ||
| Nonstandard DD recipient | 11.9% (5/42) | 0.83 | ||
| Donor age (years) | 35.0 [22.0–46.0] | 0.09 | (√) 0.02 | −0.707 ± 0.280 |
| # HLA mismatches | 3.5 [3.0–5.0] | 0.32 | ||
| First BPAR ≤180 months | 21.4% (9/42) | 0.05 | (√) 0.01 | −25.097 ± 9.219 |
| NODAT ≤180 month | 31.0% (13/42) | 0.07 | ||
| Rank {Avg CNI level: 0–180 months} | 0.52 [0.28–0.78] | 0.97 | ||
| Multivariable linear regression model for eGFR at 180 months post‐transplant (N = 42), considering the effect of rank {Avg CNI level during 0–180 months} | ||||
| Variable | Multivariable p ‐value | Model b Coeff ± SE | ||
| Donor age (years) | 0.02 | –0.729 ± 0.290 | ||
| First BPAR ≤180 months | 0.01 | –25.113 ± 9.323 | ||
| Rank {Avg CNI level: 0–180 months} | 0.72 | 4.775 ± 13.095 | ||
Note: (√) Represents selection into the multivariable linear regression model.
Abbreviations: Avg, average; BMI, body mass index; BPAR, biopsy‐proven acute rejection; CNI, calcineurin inhibitor; Coeff, coefficient; CVD, cardiovascular disease; DD, deceased donor; eGFR, estimated glomerular filtration rate; HLA, human leukocyte antigen; NODAT, new onset diabetes after transplant.
The 3 variables selected into the multivariable model were defined as follows: group C = {1 if recipient was randomized into group C, 0 otherwise}; donor age (years) (continuous variable); and first BPAR ≤180 months = {1 if the patient experienced a first BPAR during the first 180 months post‐transplant, 0 otherwise}. The estimated intercept term ± SE for the multivariable model was: 89.008 ± 11.045, and the coefficient of multiple determination was 0.22.
The 4 variables included in this multivariable model were defined as follows: donor age (years) (continuous variable); first BPAR ≤180 months = {1 if the patient experienced a first BPAR during the first 180 months post‐transplant, 0 otherwise}; and rank {Avg CNI level: 0–180 mo} = rank of the average CNI trough level during 0–180 months post‐transplant. The estimated intercept term ± SE for the multivariable model was: 87.263 ± 12.152, and the coefficient of multiple determination was 0.22.