Table 1.

Antimicrobial susceptibility profile of the 4995/20 isolate of E. faecium

Compound	MIC (mg/l)	EUCAST breakpoint (R)	ECOFFa/TECOFFb/PK/PDc	Interpretationd	Determinant
Vancomycin	> 256	> 4		R	vanA, vanB
Teicoplanin	256	> 2		R	vanA
Dalbavancin	> 256	n/a	> 0.25c	R	vanA
Oritavancin	0.06	n/a	> 0.06a,f	S	n/p
Telavancin	2	n/a	> 0.5a	R	vanA
Linezolid	8	> 4		R	poxtA
Tedizolid	1.5	n/a	> 1a	R	poxtA
Tigecycline	2	> 0.25		R	[tet(M), tet(L)]e
Tetracycline	48	n/a	> 4a	R	[tet(M), tet(L)]e
Doxycycline	32	n/a	> 0.5a	R	[tet(M), tet(L)]e
Minocycline	2	n/a	> 0.5b	R	[tet(M), tet(L)]e
Omadacycline	0.5	n/a	> 0.25a	R	[tet(M), tet(L)]e
Eravacycline	1.5	> 0.125		R	[tet(M), tet(L)]e
Penicillin	> 256	n/a	> 16a	R	n/d
Ampicillin	> 256	> 8		R	n/d
Imipenem	> 64	> 4		R	n/d
Gentamicin	> 1024	> 128		HLGR	aac(6')-aph(2'')
Streptomycin	2048	> 512		HLSR	ant(6)-Ia, ant(6')-Ii
Ciprofloxacin	> 256	> 4		R	S80I in ParC, S83I in GyrA
Levofloxacin	> 256	> 4		R	S80I in ParC, S83I in GyrA
Moxifloxacin	> 256	n/a	> 1a	R	S80I in ParC, S83I in GyrA
Rifampicin	> 256	n/a	> 8a,f	R	S491F in RpoB
Quinupristin/dalfopristin	2	> 4		S	n/p
Daptomycin	4	n/a	> 8a	S	See text
Chloramphenicol	64	n/a	> 32a	R	fexB
Erythromycin	1.5	n/a	> 4a	S	n/p
Fosfomycin	> 256	n/a	> 128a,f	R	Unknown
Nitrofurantoin (100 μg disc)	10 mm inhibition zone	< 15 mmf	< 15 mma,f	R	See text

^aECOFF, ecological cut-off (used when the EUCAST breakpoint was not available)

^bTECOFF, tentative ECOFF

^cPK/PD, pharmacokinetic/pharmacodynamic breakpoint; n/p, not applicable; n/a, not available; n/d, not determined; R, resistant; S, susceptible

^dHLGR, high-level gentamicin resistance; HLSR, high-level streptomycin resistance

^eIncreased copy number

^fAvailable for E. faecalis only