Table 1.

EGF-regulated genes are involved in cardiovascular-related functions and diseases

Categories	Diseases or Functions Annotation	B-H p value	Activation Z score
Cardiovascular Disease, Organismal Injury, and Abnormalities	Disorder of blood pressure	3.20E-09	2.200
Cardiovascular Disease, Organismal Injury and Abnormalities	Hypertension	1.09E-08	1.942
Cardiovascular System Development and Function, Organismal Development	Growth of blood vessel	1.83E-06	1.802
Cardiovascular System Development and Function	Vascularization	1.83E-05	1.787

Significantly enriched (|Z-score| ≥ 1.5, B-H p value ≤0.001) “Diseases and functions” with EGF-regulated genes were filtered for those associated with the cardiovascular system. Z-scores were calculated based on the direction of the EGF-induced regulation of the genes included in these functions and on annotations in the software internal database. Positive Z-scores correspond to putatively promoted functions or diseases. The unfiltered list of enriched functions and diseases is available in Table S2. See also Figure S2.