Table 2.
Thyroid function tests and thyroid autoantibodies at various clinical stages of hypothyroidism among women with a history of miscarriage
| Variable | Positive anti-TPO | Negative anti-TPO | P value |
|---|---|---|---|
| Euthyroid pregnant women (N = 157) N (%) | 28 (17.83%) | 129 (82.17) | |
| TSH (uIU/ml) | 1.81 ± 0.739 | 1.72 ± 0.588 | 0.492 |
| FT3 (pmol/l) | 5.16 ± 0.766 | 5.37 ± 0.757 | 0.201 |
| FT4 (pmol/l) | 16.5 ± 2.12 | 16.1 ± 2.20 | 0.450 |
| Anti-TPO (IU/ml) | 152 (36–275) | 25 (6–30) | <0.001* |
| Anti- TG (IU/ml) | 146 (10–249) | 33 (10–35) | <0.001* |
| Subclinical hypothyroid pregnant women (N = 51) | 29 (56.86%) | 22 (43.14%) | |
| TSH (uIU/ml) | 6.77 ± 1.78 | 6.24 ± 1.68 | 0.291 |
| FT3 (pmol/l) | 4.59 ± 0.640 | 4.59 ± 0.514 | 0.963 |
| FT4 (pmol/l) | 13.9 ± 1.91 | 14.4 ± 1.80 | 0.350 |
| Anti-TPO (IU/ml) | 142 (36–276) | 28 (18–34) | 0.005* |
| Anti- TG (IU/ml) | 125 (10–210) | 30 (27–45) | <0.001* |
| Clinical hypothyroid pregnant women (N = 22) | 14 (63.64%) | 8 (36.36%) | |
| TSH (uIU/ml) | 13.8 ± 7.75 | 10.9 ± 3.29 | 0.340 |
| FT3 (pmol/l) | 3.86 ± 0.543 | 3.80 ± 0.615 | 0.830 |
| FT4 (pmol/l) | 10.2 ± 1.49 | 10.9 ± 0.756 | 0.230 |
| Anti-TPO (IU/ml) | 195(38–272) | 29(25–32) | 0.041* |
| Anti- TG(IU/ml) | 140(30–250) | 30(26–33) | 0.008* |
Quantitative variables are presented as mean ±SD or median (min, max)
Test of significance: (t): independent samples t-test. Mann-Whitney U test
TSH Thyroid-stimulating hormone, FT3 free tri-iodothyronine, FT4 free tetra-iodothyronine, anti-TPO anti-thyroid peroxidase antibody, anti-TG anti-thyroglobulin antibody