Table 3.
Basic information on studies using pharmacological interventions
| Author | Year | Medication | Study type | Imaging tool and indicator | Animal and modeling method | Conclusion | Relevance |
|---|---|---|---|---|---|---|---|
| Sun et al. [33] | 2021 | Denosumab | Animal experiment | Micro-CT: DHI; BV/TV; Tb.Th; Tb.N; Tb.Sp; Po. N (cl);Po (op); Po. V (tot) |
SD rats female a total of 60, 12 per group OVX |
Denosumab delays the degeneration of adjacent discs after lumbar fusion. This protective effect is mainly achieved by inhibiting osteoporosis and endplate cartilage remodeling | Positive correlation |
| Luo et al. [34] | 2013 | Alendronate | Animal experiment |
DEXA: BMD Micro-CT: BV/TV; Tb.Th; Tb.N; Tb.Sp; SMI |
SD rats female a total of 30, 10 per group OVX |
Alendronate delays the progression of disc degeneration in OVX rats. The mechanism may be related to the protection of the structural integrity of the vertebral body and endplate | Positive correlation |
| Liu et al. [35] | 2018 | 17β-estradiol | Animal experiment | Micro-CT: IDH; VEL; BV/TV; Tb.N; Tb.Th; Tb.Sp |
SD rats female a total of 72 OVX |
Estrogen deficiency exacerbates disc degeneration caused by spinal instability, and estrogen supplementation reduces the progression of disc degeneration | Positive correlation |
| Luo et al. [36] | 2014 | Salmon calcitonin | Animal experiment | Micro-CT: BV/TV; Tb.Th; Tb.N; Tb.Sp; SMI |
SD rats female a total of 30, 10 per group OVX |
Salmon calcitonin delays the progression of disc degeneration in OVX rats. The mechanism may be related to the protection of the structural integrity of the vertebral body and the regulation of the expression of MMPs, aggrecan and type II collagen | Positive correlation |
| Chen et al. [37] | 2018 | Sintered dicalcium pyrophosphate | Animal experiment |
Micro-CT: BV/TV; Tb.Th; Tb.Sp; Tb.N; BMD |
SD rats female a total of 60, 20 per group OVX |
Sintered dicalcium pyrophosphate prevents osteoporosis and improves disc degeneration in rats | Positive correlation |
| Luo et al. [38] | 2018 | Parathyroid hormone 1–34 | Animal experiment |
DEXA: BMD Micro-CT: BV/TV; Tb.N; Tb.Th; Tb.Sp; SMI |
SD rats female a total of 30, 15 per group OVX |
Parathyroid hormone 1–34 has a significant promotion effect on bone mass and bone strength in OVX rats, but no significant effect on disc degeneration | Irrelevant |