TABLE 2.
Pharmacological reactivity of pig coronary veins and arteries.
| Vein | Artery | Significance | |
|---|---|---|---|
| Noradrenaline | |||
| Maximal response, relative to high-K+ tension | 0.48 ± 0.15, n = 14 | −0.03 ± 0.01, n = 12 | p < 0.001 |
| U46619 | |||
| Maximal response, relative to high- K+ tension | 1.68 ± 0.24, n = 8 | 1.26 ± 0.09, n = 14 | p < 0.05 |
| Hill (h) coefficient | 1.09 ± 0.07, n = 8 | 1.70 ± 0.15, n = 16 | p < 0.01 |
| EC 50 , log M | −7.72 ± 0.04, n = 8 | −7.56 ± 0.09, n = 16 | n.s. |
| Acetylcholine | |||
| Maximal response, relative to high-K+ tension | 0.25 ± 0.06, n = 8 | 1.03 ± 0.17, n = 14 | p < 0.01 |
| Hill (h) coefficient | 1.46 ± 0.08, n = 15 | ||
| EC 50 , log M | −7.02 ± 0.08, n = 15 |
Sensitivity to noradrenaline, the thromboxane analogue U46619 and acetylcholine were determined, and the hyperbolic Hill equation Eq. 1 was fitted to the data to determine the maximal response at saturating concentration, the Hill (h) coefficient and the EC 50 values. The maximal response is given relative to the high-K+ induced tension. Three to six animals were used for arteries and veins, respectively. Statistical comparisons were made using Student’s t-test or Mann-Whitney rank sum test for the maximal response to noradrenaline, U46619, and acetylcholine (in the veins for acetylcholine curve fits could not be performed and the maximal response was obtained from tension at the highest dose).