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. 2023 Nov 2;14:1235337. doi: 10.3389/fgene.2023.1235337

FIGURE 2.

FIGURE 2

Interaction effects of Locus 15 (rs35287906; STIM1) identified through combined Stage 1 and Stage 2 interaction effects with GradCol for LDL in EUR and CPA. Forest plots show β values (95% confidence intervals) and p-values (1 DF) for the rs35287906 × GradCol interaction term in linear regression models of LDL adjusted for age, sex, field center (for multi-center studies), and principal components. Results shown are for each EUR study, as well as the population-specific combined Stage 1 and 2 meta-analysis results. The interaction effect βG Educ corresponds to the difference in genetic effects between higher (βG1 = −5.25 mg/dL per minor allele) and lower education (βG0 = 3.41 mg/dL per minor allele), for a combined interaction effect of −8.66 mg/dL. AF, coded allele frequency; N, sample size.