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A proposed model illustrating the action and mechanism of integrin αvβ1 that facilitates ACE2-mediated viral entry of SARS-CoV-2
A. ACE2 functions as an independent receptor for SARS-CoV-2 entry into the host cells;
B. Integrin αvβ1 is unable to serve as an independent receptor for SARS-CoV-2 entry into the host cells;
C. Integrin αvβ1 may significantly enhance the ACE2-mediated viral entry of SARS-CoV-2.
