Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Nov 15;13:19927. doi: 10.1038/s41598-023-43099-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Effects of Cap on BO-induced oxidative stress in cardiac muscle. (A) Representative immunohistochemical images of oxidative DNA damage (8-OHdG) in cardiac muscle in the Control (upper left), BO (upper right), captopril (Cap; lower left) and BO + Cap (lower right) groups. Scale bar = 5 μm. (B) 8-OHdG-positive nuclei were significantly increased in the BO group (n = 5), but this increase was blocked in the BO + Cap group (n = 5). *P < 0.05, **P < 0.01 by one-way ANOVA followed by the Tukey–Kramer post hoc test. (C) NOX4 expression was significantly increased in the BO group (n = 6), and this increase was significantly blocked in the BO + Cap group (n = 6). *P < 0.05 by one-way ANOVA followed by the Tukey–Kramer post hoc test. Data are presented as mean ± SD and dots show individual data. Images of full-size immunoblots are shown in Supplementary Fig. 9. (D) Expression of XO was significantly increased in the BO group (n = 6), and this increase was significantly blocked in the BO + Cap group (n = 6). *P < 0.05 by one-way ANOVA followed by the Tukey–Kramer post hoc test. Data are presented as mean ± SD and dots show individual data. Images of full-size immunoblots are shown in Supplementary Fig. 10.